Regulation of HoxA expression in developing and regenerating axolotl limbs
نویسندگان
چکیده
منابع مشابه
Regulation of HoxA expression in developing and regenerating axolotl limbs.
Homeobox genes are important in the regulation of outgrowth and pattern formation during limb development. It is likely that homeobox genes play an equally important role during limb regeneration. We have isolated and identified 17 different homeobox-containing genes expressed by cells of regenerating axolotl limbs. Of these, nearly half of the clones represent genes belonging to the HoxA compl...
متن کاملPitx1 expression in developing and regenerating axolotl limbs.
The expression of the homeobox transcription factor Pitx1 was investigated in the Mexican axolotl (Ambystoma mexicanum) during limb development and regeneration by whole-mount mRNA in situ hybridizations. This clone shares high amino acid identity with Pitx1 from other vertebrates (92% Xenopus; 87% chick; 75% human and mouse) within the region isolated. In the developing limbs, Pitx1 was expres...
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HoxA genes exhibit central roles during development and causal mutations have been found in several human syndromes including limb malformation. Despite their importance, information on how these genes are regulated is lacking. Here, we report on the first identification of bona fide transcriptional enhancers controlling HoxA genes in developing limbs and show that these enhancers are grouped i...
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The applicability of deterministic models, and in particular the polar co-ordinate model of French, Bryant & Bryant (1976), to the regenerative process has been investigated by performing ipsilateral blastemal rotations of varying angle on the fore and hind limbs of the axolotl. The results show that the frequency of supernumerary production rises with increasing angle to reach a peak at 180 de...
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Ectopic retinoic acid (RA) has been hypothesized to reprogram the positional identity of cells in developing and regenerating limbs to a single positional value corresponding to the posterior-ventral-proximal (PVPr) position on the limb. We tested this hypothesis by using RA to reprogram the information of blastema cells that were induced to form at different positions around the limb circumfer...
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ژورنال
عنوان ژورنال: Development
سال: 1995
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.121.6.1731